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会议日期
2024年11月15-17日
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投稿截止日期
2024年10月15日
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早期线上缴费优惠截止日期
2024年10月15日
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现场报到日期
2024年11月15日
Hai Qi
Tsinghua University School of Medicine
Dr. Qi received his Bachelor of Medicine from the Beijing Medical University and Ph.D. in Pathology from the University of Texas Medical Branch at Galveston. After postdoctoral training at NIH, he joined the School of Medicine, Tsinghua University in 2009, where he is currently a Professor in Immunology. He has made important contributions to our understanding of germinal center biology, T cell-B cell interactions, B-cell immune memory, and neuroimmune regulation of humoral immunity. Dr. Qi is an HHMI International Research Scholar and a New Cornerstone Investigator, and he has received numerous awards including the 2018 AAI-BD Investigator Award.
Talk title: Neuronal control of B cell immunity: how and why
I will present our published and unpublished work pertaining to how and why antibody immunity is regulated by the brain in response to external conditions.
Selected publications:
1. Heping Xu, Xuanying Li, Dan Liu, Jianfu Li, Xu Zhang, Xin Chen, Shiyue Hou, Lixia Peng, Chenguang Xu, Wanli Liu, Lianfeng Zhang, and Hai Qi#. Follicular T-helper cell recruitment governed by bystander B cells and ICOS-driven motility. Nature 496:523-527, 2013.
2. Dan Liu*, Heping Xu*, Changming Shih, Zurong Wan, Xiaopeng Ma, Weiwei Ma, Dan Luo, and Hai Qi#. T-B-cell entanglement and ICOSL-driven feed-forward regulation of germinal centre reaction. Nature, 517:214-218, 2015.
3. Peiwen Lu*, Changming Shih*, and Hai Qi#. Ephrin B1-mediated repulsion and signaling control germinal center T cell territoriality and function. Science, 356:eaai9264, 2017.
4. Yifeng Wang*, Jingwen Shi*, Jiacong Yan*, Zhengtao Xiao, Xiaoxiao Hou, Peiwen Lu, Shiyue Hou, Tianyang Mao, Wanli Liu, Yuanwu Ma, Lianfeng Zhang, Xuerui Yang and Hai Qi#. Germinal center development of memory B cells driven by Interleukin-9-producing follicular T-helper cells. Nature Immunology, 18:921-930, 2017.
5. Ruozhu Zhao, Xin Chen, Weiwei Ma, Jinyu Zhang, Jie Guo, Xiu Zhong, Jiacheng Yao, Jiahui Sun, Julian Rubinfien, Xuyu Zhou, Jianbin Wang and Hai Qi#. A GPR174-CCL21 module imparts sexual dimorphism to humoral immunity. Nature, 577:416-420, 2020.
6. Xu Zhang*, Bo Lei*, Yuan Yuan*, Li Zhang*, Lu Hu, Sen Jin, Bilin Kang, Xuebin Liao, Wenzhi Sun, Fuqiang Xu, Yi Zhong#, Ji Hu# and Hai Qi#. Brain control of humoral immune responses amenable to behavioral modulation. Nature, 581:204-208, 2020.
7. Bo Liu, Yihan Lin, Jiacong Yan, Jiacheng Yao, Dan Liu, Weiwei Ma, Jianbin Wang, Wanli Liu, Chengshuo Wang, Luo Zhang, and Hai Qi#. Affinity-coupled CCL22 promotes germinal-center positive selection. Nature, 2021.
8. Xin Liu*, Jiacheng Yao*, Yongshan Zhao, Jianbin Wang#& Hai Qi#. Heterogeneous plasma cells and long-lived subsets in response to immunization, autoantigen and microbiota. Nature Immunology, 23, 1564-1576, 2022.
9. Yifeng Wang*, Wen Shao*, Xin Liu, Qingtai Liang, Jiaqi Lei, Wenjuan Shi, Miao Mei, Ying Li, Xu Tan, Guocan Yu, Li Yu, Linqi Zhang, and Hai Qi#. High recallability of memory B cells requires ZFP318-dependent transcriptional regulation of mitochondrial function. Immunity, (doi: 10.1016/j.immuni.2024.05.022, 2024)
10. Wen Shao*, Yifeng Wang*, Qian Fang, Wenjuan Shi, and Hai Qi#. Epigenetic recording of stimulation history reveals BLIMP1-BACH2 balance in determining memory B cell fate upon recall challenge. Nature Immunology, (doi: 10.1038/s41590-024-01900-2, 2024)
Talk title: Neuronal control of B cell immunity: how and why
I will present our published and unpublished work pertaining to how and why antibody immunity is regulated by the brain in response to external conditions.
Selected publications:
1. Heping Xu, Xuanying Li, Dan Liu, Jianfu Li, Xu Zhang, Xin Chen, Shiyue Hou, Lixia Peng, Chenguang Xu, Wanli Liu, Lianfeng Zhang, and Hai Qi#. Follicular T-helper cell recruitment governed by bystander B cells and ICOS-driven motility. Nature 496:523-527, 2013.
2. Dan Liu*, Heping Xu*, Changming Shih, Zurong Wan, Xiaopeng Ma, Weiwei Ma, Dan Luo, and Hai Qi#. T-B-cell entanglement and ICOSL-driven feed-forward regulation of germinal centre reaction. Nature, 517:214-218, 2015.
3. Peiwen Lu*, Changming Shih*, and Hai Qi#. Ephrin B1-mediated repulsion and signaling control germinal center T cell territoriality and function. Science, 356:eaai9264, 2017.
4. Yifeng Wang*, Jingwen Shi*, Jiacong Yan*, Zhengtao Xiao, Xiaoxiao Hou, Peiwen Lu, Shiyue Hou, Tianyang Mao, Wanli Liu, Yuanwu Ma, Lianfeng Zhang, Xuerui Yang and Hai Qi#. Germinal center development of memory B cells driven by Interleukin-9-producing follicular T-helper cells. Nature Immunology, 18:921-930, 2017.
5. Ruozhu Zhao, Xin Chen, Weiwei Ma, Jinyu Zhang, Jie Guo, Xiu Zhong, Jiacheng Yao, Jiahui Sun, Julian Rubinfien, Xuyu Zhou, Jianbin Wang and Hai Qi#. A GPR174-CCL21 module imparts sexual dimorphism to humoral immunity. Nature, 577:416-420, 2020.
6. Xu Zhang*, Bo Lei*, Yuan Yuan*, Li Zhang*, Lu Hu, Sen Jin, Bilin Kang, Xuebin Liao, Wenzhi Sun, Fuqiang Xu, Yi Zhong#, Ji Hu# and Hai Qi#. Brain control of humoral immune responses amenable to behavioral modulation. Nature, 581:204-208, 2020.
7. Bo Liu, Yihan Lin, Jiacong Yan, Jiacheng Yao, Dan Liu, Weiwei Ma, Jianbin Wang, Wanli Liu, Chengshuo Wang, Luo Zhang, and Hai Qi#. Affinity-coupled CCL22 promotes germinal-center positive selection. Nature, 2021.
8. Xin Liu*, Jiacheng Yao*, Yongshan Zhao, Jianbin Wang#& Hai Qi#. Heterogeneous plasma cells and long-lived subsets in response to immunization, autoantigen and microbiota. Nature Immunology, 23, 1564-1576, 2022.
9. Yifeng Wang*, Wen Shao*, Xin Liu, Qingtai Liang, Jiaqi Lei, Wenjuan Shi, Miao Mei, Ying Li, Xu Tan, Guocan Yu, Li Yu, Linqi Zhang, and Hai Qi#. High recallability of memory B cells requires ZFP318-dependent transcriptional regulation of mitochondrial function. Immunity, (doi: 10.1016/j.immuni.2024.05.022, 2024)
10. Wen Shao*, Yifeng Wang*, Qian Fang, Wenjuan Shi, and Hai Qi#. Epigenetic recording of stimulation history reveals BLIMP1-BACH2 balance in determining memory B cell fate upon recall challenge. Nature Immunology, (doi: 10.1038/s41590-024-01900-2, 2024)
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